Pathologic Types of Breast Cancer

According to the the latest (2003) WHO classification of tumors of the breast (wikipedia)

Invasive breast carcinomas

• Invasive ductal carcinoma
  • Most are "not otherwise specified"
  • The remainder are given subtypes:
    • Mixed type carcinoma
    • Pleomorphic carcinoma
    • Carcinoma with osteoclastic giant cells
    • Carcinoma with choriocarcinomatous features
    • Carcinoma with melanotic features
• Invasive lobular carcinoma
• Tubular carcinoma
• Invasive cribriform carcinoma
• Medullary carcinoma
• Mucinous carcinoma and other tumours with abundant mucin
  • Mucinous carcinoma
  • Cystadenocarcinoma and columnar cell mucinous carcinoma
  • Signet ring cell carcinoma
• Neuroendocrine tumours
  • Solid neuroendocrine carcinoma (carcinoid of the breast)
  • Atypical carcinoid tumour
  • Small cell / oat cell carcinoma
  • Large cell neuroendocrine carcioma
• Invasive papillary carcinoma
• Invasive micropapillary carcinoma
• Apocrine carcinoma
• Metaplastic carcinomas
  • Pure epithelial metaplastic carciomas
    • Squamous cell carcinoma
    • Adenocarcinoma with spindle cell metaplasia
    • Adenosquamous carcinoma
    • Mucoepidermoid carcinoma
  • Mixed epithelial/mesenchymal metaplastic carcinomas
• Lipid-rich carcinoma
• Secretory carcinoma
• Oncocytic carcinoma
• Adenoid cystic carcinoma
• Acinic cell carcinoma
• Glycogen-rich clear cell carcinoma
• Sebaceous carcinoma
• Inflammatory carcinoma
• Bilateral breast carcinoma

Precursor lesions

• Lobular neoplasia
  • lobular carcinoma in situ
• Intraductal proliferative lesions
  • Usual ductal hyperplasia
  • Flat epithelial hyperplasia
  • Atypical ductal hyperplasia
  • Ductal carcinoma in situ
• Microinvasive carcinoma
• Intraductal papillary neoplasms
  • Central papilloma
  • Peripheral papilloma
  • Atypical papilloma
  • Intraductal papillary carcinoma
  • Intracystic papillary carcinoma

Benign epithelial lesions

• Adenosis, includin variants
  • Sclerosing adenosis
  • Apocrine adenosis
  • Blunt duct adenosis
  • Microglandular adenosis
  • Adenomyoepithelial adenosis
• Radial scar / complex sclerosing lesion
• Adenomas
  • Tubular adenoma
  • Lactating adenoma
  • Apocrine adenoma
  • Pleomorphic adenoma
  • Ductal adenoma

Myoepithelial lesions

• Myoepitheliosis
• Adenomyoepithelial adenosis
• Adenomyoepithelioma
• Malignant myoepithelioma

Mesenchymal tumors (including sarcoma)

• Haemangioma
• Angiomatosis
• Haemangiopericytoma
• Pseudoangiomatous stromal hyperplasia
• Myofibroblastoma
• Fibromatosis (agressive)
• Inflammatory myofibroblastic tumour
• Lipoma
  • Angiolipoma
• Granular cell tumour
• Neurofibroma
• Schwannoma
• Angiosarcoma
• Liposarcoma
• Rhabdomyosarcoma
• Osteosarcoma
• Leiomyoma
• Leiomysarcoma

Fibroepithelial tumours

• Fibroadenoma
• Phyllodes tumour
  • Benign
  • Borderline
  • Malignant
• Periductal stromal sarcoma, low grade
• Mammary hamartoma

Tumours of the nipple

• Nipple adenoma
• Syringomatous adenoma
• Paget's disease of the nipple

Malignant lymphoma

metastatic tumours

Tumours of the male breast

• Gynecomastia
• Carcinoma
  • In situ
  • Invasive